Key facts
- A total of 1.23 million people died from tuberculosis (TB) in 2024 (including 150 000 among people with HIV). Globally, TB is the world’s leading cause of death from a single infectious agent and among the top 10 causes of death.
- TB was also both the leading killer of people with HIV in 2024 and a major cause of deaths related to antimicrobial resistance.
- In 2024, an estimated 10.7 million people fell ill with TB worldwide, including 5.8 million men, 3.7 million women and 1.2 million children. TB is present in all countries and age groups.
- Multidrug-resistant TB (MDR-TB) remains a public health crisis and a health security threat. Only about 2 in 5 people with drug-resistant TB accessed treatment in 2024.
- Global efforts to combat TB have saved an estimated 83 million lives since the year 2000.
- TB is preventable and curable.
Overview
Tuberculosis (TB) is an infectious disease caused by bacteria that most often affects the lungs. It spreads through the air when people with TB cough, sneeze or spit
Tuberculosis is preventable and curable
About a quarter of the global population is estimated to have been infected with TB bacteria. In general, people with TB infection don’t feel sick and are not contagious. About 5–10% of people infected with TB will eventually get symptoms and develop TB disease. Babies and children are at higher risk of developing the disease if they are infected
TB disease is usually treated with antibiotics and can be fatal without treatment
In certain countries, the Bacille Calmette-Guérin (BCG) vaccine is given to babies or small children to prevent TB. The vaccine prevents deaths from TB and protects children from serious forms of TB
Certain conditions can increase a person’s risk for TB disease:
- diabetes (high blood sugar);
- weakened immune system (for example, from HIV);
- undernutrition;
- tobacco use; and
- harmful use of alcohol.
Symptoms
In general, people with TB infection don’t feel sick and are not contagious. Only a small proportion of people who get infected with TB will get TB disease and develop symptoms. Babies and children are at higher risk of developing the disease if they are infected
TB disease occurs when bacteria multiply in the body and affect different organs. TB symptoms may be mild for many months, so it is easy to spread TB to others without knowing it. Symptoms depend on which part of the body is affected. While TB usually affects the lungs, it can also affect the kidneys, brain, and spine
Some people with TB disease do not have any symptoms but can still spread TB
Common symptoms of TB are:
- prolonged cough (sometimes with blood);
- chest pain;
- weakness;
- fatigue;
- weight loss;
- fever; and
- night sweats
The symptoms people get depend on which part of the body is affected by TB. While TB usually affects the lungs, it can also involve the kidneys, brain, spine and skin
Prevention
Follow these steps to help prevent tuberculosis infection and spread:
- Seek medical attention if you have symptoms like prolonged cough, fever and unexplained weight loss as early treatment for TB can help stop the spread of disease and improve your chances of recovery.
- Get screened for TB if you are at increased risk, such as if you have HIV or are in contact with people who have TB in your household or workplace.
- TB preventive treatment (or TPT) prevents infection from becoming disease. If prescribed TPT, complete the full course.
- If you have TB, practice good hygiene when coughing, including avoiding contact with other people and wearing a mask, covering your mouth and nose when coughing or sneezing, and disposing of sputum and used tissues properly.
- Special measures, like respirators and well-ventilated spaces are important to reduce infection in healthcare facilities and other institutions.
Diagnosis
WHO recommends the use of rapid diagnostic tests as the initial diagnostic tests in all persons with signs and symptoms of TB
Rapid diagnostic tests recommended by WHO include biomarker-based point-of-care tests and molecular assays. All these tests are accurate and can provide initial results to guide treatment decisions within 48 hours of sample collection. Use of these tests will lead to major improvements in the early detection of TB and drug-resistant TB
Diagnosing drug-resistant forms of TB, including multidrug-resistant TB, as well as HIV-associated TB and pediatric TB can be complex. WHO recommends specific sample types, tests and strategies to detect these forms of TB to increase the chances of detecting disease early and accurately
A tuberculin skin test (TST), interferon gamma release assay (IGRA) or newer antigen-based skin test (TBST) can be used to identify people with TB infection. The results from these TB infection tests are used to identify which individuals with a high risk of TB will benefit most from TB preventive treatment
Treatment
Tuberculosis disease is treated with special antibiotics. Treatment is recommended for both TB infection and disease
The most common antibiotics used are:
- rifampicin;
- isoniazid;
- pyrazinamide; and
- ethambutol.
To be effective, medications need to be taken daily for 4–6 months. It is dangerous to stop the medications early or without medical advice as it can prompt TB bacteria in the body to become resistant to the antibiotics
TB that doesn’t respond to standard drugs is called drug-resistant TB and requires treatment with different medicines
Multidrug-resistant TB (MDR-TB)
Drug resistance emerges when TB medicines are used inappropriately, through incorrect prescription by health care providers, poor quality drugs, or patients stopping treatment prematurely
MDR-TB is a form of TB caused by bacteria that do not respond to rifampicin and isoniazid, the two most effective first-line TB drugs. MDR-TB is treatable and curable by using other drugs, which tend to be more expensive and with more side effects. People exposed to MDR-TB may receive TB preventive treatment with levofloxacin
In some cases, extensively drug-resistant TB or XDR-TB can develop. TB caused by bacteria that do not respond to the most effective drugs in MDR-TB treatment regimens can leave patients with very limited treatment options
MDR-TB remains a public health crisis. Only about 2 in 5 people with multidrug-resistant TB accessed treatment in 2024
In accordance with WHO guidelines, detection of MDR-TB requires bacteriological confirmation of TB and testing for drug resistance using rapid molecular tests or culture methods
In 2022, new WHO guidelines prioritized a short 6-month all-oral regimen known as BPaLM/BPaL as a treatment of choice for eligible patients. Globally in 2024, approximately 34 000 people with MDR/RR-TB were reported to have started treatment on the 6-month shorter regimens (known as BPaLM and BDLLfxC), a substantial increase from 5653 in 2023 and 1744 in 2022. The shorter duration, lower pill burden and high efficacy of this novel regimen can help ease the burden on health systems and save precious resources to further expand the diagnostic and treatment coverage for all individuals in need. WHO recommends expanded access to all-oral regimens.
TB and HIV
People living with HIV are 12 times more likely to fall ill with TB disease than people without HIV. TB is the leading cause of death among people with HIV
HIV and TB form a lethal combination, each accelerating the other’s progress. In 2024, about 150 000 people died of HIV-associated TB. The percentage of people who fell ill with TB and had a documented HIV test result was 82% in 2024. This was a slight increase from 81% in 2023. The WHO African Region has the highest burden of HIV-associated TB. Globally in 2024, only 61% of the estimated number of people living with HIV who developed TB received antiretroviral therapy (ART).
WHO first recommended collaborative TB/HIV activities to reduce morbidity and mortality from HIV-associated TB in 2004. These activities include bidirectional screening, prevention and treatment of infection and disease. Scale-up of TB treatment and ART since 2005 is estimated to have averted 9.8 million deaths
Impact
TB mostly affects adults in their most productive years. However, all age groups are at risk. Over 80% of cases and deaths are in low- and middle-income countries
TB occurs in every part of the world. In 2024, the largest number of new TB cases occurred in the WHO South-East Asia Region (34%), followed by the Western Pacific Region (27%) and the African Region (25%). Around 87% of new TB cases occurred in the 30 high TB burden countries, with two-thirds of the global total in India (25%), Indonesia (10%), the Philippines (6.8%), China (6.5%), Pakistan (6.3%), Nigeria (4.8%), the Democratic Republic of the Congo (3.9%) and Bangladesh (3.6%). The top five countries accounted for 55% of the global total.
Globally, about 50% of people treated for TB and their households face total costs (direct medical expenditures, non-medical expenditures and indirect costs such as income losses) that are catastrophic (>20% of total household income). This is far from the target of the WHO End TB Strategy of zero. Those with compromised immune systems, such as people living with HIV, undernutrition or diabetes, or people who use tobacco have a higher risk of falling ill. Globally in 2024, there were an estimated 0.97 million new TB cases that were attributable to undernutrition, 0.93 million to diabetes, 0.74 million to alcohol use disorders, 0.70 million to smoking and 0.57 million to HIV infection.
Investments to end TB
US$ 22 billion are needed annually for TB prevention, diagnosis, treatment and care to achieve global targets by 2027 agreed on at the 2023 UN high level-TB meeting
As in the past decade, most of the spending on TB services in 2024 (82%) was from domestic sources. In absolute terms, Brazil, China, India, the Russian Federation and South Africa accounted for US$ 3.1 billion (64%) of the total of US$ 4.8 billion provided from domestic sources in low- and middle-income countries (LMICs), international donor funding amounted to US$ 1.1 billion, having ranged from US$ 1.1 billion to US$ 1.2 billion in almost every year since 2015. Financing for TB research and innovation, at US$ 1.2 billion in 2023, also continues to fall far short of the global target of US$ 5 billion per year. Progress to date has been constrained by the overall level of investment.
WHO response
WHO is working closely with countries, partners and civil society to scaler up the TB response. Six core functions are being pursued by WHO to contribute to achieving the targets of the 2023 UN High-level Meeting political declaration, Sustainable Development Goals, the WHO End TB Strategy and WHO strategic priorities
